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Type: Artigo de periódico
Title: Survival of women with ovarian carcinomas and borderline tumors is not affected by estrogen and progesterone receptor status
Author: Sallum, LF
Sarian, LO
Andrade, LLD
Vassallo, J
Soares, FA
Pinto, GA
Ferreira, PA
Derchain, S
Abstract: Objective: To examine the patterns of estrogen receptor (ER) and progesterone receptor (PR) expression in borderline ovarian tumors (BOTs) and ovarian carcinomas. We also assessed the disease-free survival (DFS) and overall survival (OS) in women with ovarian carcinoma, in relation to ER and/or PR expression. Methods: We examined ER/PR expression in 38 BOTs and 172 ovarian carcinomas removed from patients treated at the State University of Campinas-UNICAMP (Brazil), from 1993 to 2008 and followed for up to 60 months using tissue microarray-based immunohistochemistry. Results: Twenty-eight (73.7%) mucinous and 10 (26.3%) serous BOTs were included. Ovarian carcinomas consisted mainly of 79 (46.0%) serous, 44 (25.5%) mucinous, 17 (9.8%) endometrioid, 10 (5.8%) clear-cell types. There was no significant difference of the ER/PR expression between BOT and ovarian carcinoma (p=0.55 for ER alone, 0.90 for PR alone, and 0.12 for combined expression). The level of ER/PR expression in BOTs was significantly higher in serous than in mucinous tumors (p<0.01). In carcinomas, ER/PR was higher in serous tumors than in mucinous (p<0.01) and clear cell tumors (p=0.02), and higher in endometrioid tumors than in mucinous tumors (p<0.01). DES was affected neither by the clinical characteristics nor by combined steroid receptor status. OS was found to be significantly worse (p<0.01) only in women with stages II-IV tumors and those with residual disease after surgery (p<0.01). Conclusion: Overall, serous and endometrioid tumors were predominantly ER/PR positive, whereas mucinous and clear-cell tumors were preponderantly ER/PR negative. DFS and OS were not affected by ER/PR expression.
Subject: Borderline ovarian tumor
Estrogen receptor
Ovarian carcinoma
Progesterone receptor
Tissue microarray
Country: Coreia do Sul
Editor: Korean Soc Gynecology Oncology & Colposcopy
Citation: Journal Of Gynecologic Oncology. Korean Soc Gynecology Oncology & Colposcopy, v. 24, n. 2, n. 167, n. 176, 2013.
Rights: fechado
Identifier DOI: 10.3802/jgo.2013.24.2.167
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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