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Type: Artigo de periódico
Title: Syntheses of some 4-anilinoquinazoline derivatives
Author: Rocco, SA
Barbarini, JE
Rittner, R
Abstract: Some 4-N-(3'- or 4'-substituted-phenyl)amino-6,7-dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.
Subject: 4-anilinoquinazolines
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Citation: Synthesis-stuttgart. Georg Thieme Verlag Kg, n. 3, n. 429, n. 435, 2004.
Rights: aberto
Identifier DOI: 10.1055/s-2004-815949
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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