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Type: Artigo de periódico
Title: Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues
Author: Russowsky, D
Canto, RFS
Sanches, SAA
D'Oca, MGM
de Fatima, A
Pilli, RA
Kohn, LK
Antonio, MA
de Carvalho, JE
Abstract: The synthesis and differential antiproliferative activity of monastrol (1a), oxo-monastrol (1b) and eight oxygenated derivatives 3a,b-6a,b on seven human cancer cell lines are described. For all evaluated cell lines, monastrol (1a) was shown to be more active than its oxo-analogue, except for HT-29 cell line, suggesting the importance of the sulfur atom for the antiproliferative activity. Monastrol (1a) and the thio-derivatives 3a, 4a and 6a displayed relevant antiproliferative properties with 3,4-methylenedioxy derivative 6a being approximately more than 30 times more potent than monastrol (1a) against colon cancer (HT-29) cell line. (c) 2006 Elsevier Inc. All rights reserved.
Subject: monastrol
mitotic kinesin Eg5
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Bioorganic Chemistry. Academic Press Inc Elsevier Science, v. 34, n. 4, n. 173, n. 182, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.bioorg.2006.04.003
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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