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Type: Artigo de periódico
Title: SHP-2 regulates myogenesis by coupling to FAK signaling pathway
Author: de Oliveira, MV
Marin, TM
Clemente, CF
Dalla Costa, AP
Judice, CC
Franchini, KG
Abstract: Transient dephosphorylation of FAK at Tyr-397 is required for cell cycle withdrawal early on during myogenesis. Here, we show that upon serum starvation of C2C12 myoblasts, FAK is transiently dephosphorylated in parallel with SHP-2 activation and association with FAK. SHP-2 knockdown by RNA interference suppressed the transient upregulation of SHP-2 and dephosphorylation of FAK during myogenesis. Furthermore, depletion of SHP-2 retarded the cell cycle withdrawal and the differentiation of serum-starved myoblasts into myotubes. These data provide a mechanistic basis for the reduction in FAK activity in differentiating myoblasts, indicating that myogenesis is critically triggered by FAK/SHP-2 complex.
Subject: Myogenesis
Skeletal muscle
Cell signaling
Cell proliferation
Cell differentiation
Country: Holanda
Editor: Elsevier Science Bv
Citation: Febs Letters. Elsevier Science Bv, v. 583, n. 18, n. 2975, n. 2981, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2009.08.022
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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