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Type: Artigo de periódico
Title: Serological profiles and evaluation of parasitaemia by PCR and blood culture in individuals chronically infected by Trypanosoma cruzi treated with benzonidazole
Author: Aguiar, C
Batista, AM
Pavan, TBS
Almeida, EA
Guariento, ME
Wanderley, JS
Costa, SCB
Abstract: Objective To evaluate the serological and parasitological status of patients with chronic Chagas disease (CD) after chemotherapy with benzonidazole. methods Retrospective study of patients treated with benzonidazole (5 mg/kg /day for 60 days) between 1980 and 2010. Twenty-nine patients who had CD confirmed by two reagent immunological tests and /or one positive xenodiagnosis before treatment were included. Conventional serology (ELISA and IIF) and parasitological tests (haemoculture and N-PCR) were performed. results At the time of treatment, the mean age of patients was 36 +/- 7.24 years (20-39 years) and the time post-treatment varied from 1 to 29 years. After chemotherapy, all individuals had reagent ELISA and 93.1% had positive results for the IIF test. T. cruzi DNA was detected by N-PCR in 48.3%. Negative results were observed in 41.4% and inconclusive ones in 10.3%. Haemoculture was negative for all individuals. conclusions Our results suggest that N-PCR may be useful in the early identification of therapeutic failure of CD. Although it is difficult to determine parasitological cure in negative N-PCR cases, we can infer that this condition represents a declination of parasitaemia as a favourable consequence of aetiological treatment.
Subject: Chagas disease
Country: EUA
Editor: Wiley-blackwell
Citation: Tropical Medicine & International Health. Wiley-blackwell, v. 17, n. 3, n. 368, n. 373, 2012.
Rights: fechado
Identifier DOI: 10.1111/j.1365-3156.2011.02936.x
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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