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Type: Artigo de periódico
Title: Sex-specific hemodynamic and non-hemodynamic determinants of aortic root size in hypertensive subjects with left ventricular hypertrophy
Author: Cipolli, JAA
Souza, FAS
Ferreira-Sae, MCS
Pio-Magalhaes, JA
Figueiredo, ES
Vidotti, VG
Matos-Souza, JR
Franchini, KG
Nadruz, W
Abstract: Aortic root (AoR) dilatation is more frequently observed in hypertensive individuals and is independently associated with left ventricular (LV) hypertrophy. Although the LV structure has sex-specific predictors, it remains unknown whether there are gender-related differences in the determinants of AoR size. We carried out a cross-sectional analysis of clinical, laboratory, anthropometric, funduscopic and echocardiographic features of 438 hypertensive patients with LV hypertrophy (266 women and 172 men). Women with enlarged AoR had higher cardiac output (P=0.0004), decreased peripheral vascular resistance (P=0.009), higher prevalence of mild aortic regurgitation (P=0.02) and increased waist circumference (P=0.04), whereas AoR-dilated men presented with a higher prevalence of concentric LV hypertrophy (P=0.0008) and mild aortic regurgitation (P=0.005) and increased log C-reactive protein levels (P=0.02), compared with sex-matched normal AoR subjects. In women, AoR dilatation associated with cardiac output, mild aortic regurgitation and waist circumference in a multivariate model including age, body surface area, height, homeostasis model assessment index, LV mass index, diastolic blood pressure, menopause status and use of antihypertensive medications as independent variables. Conversely, AoR dilatation associated with LV relative wall thickness, log C-reactive protein and mild aortic regurgitation without contributions from diastolic blood pressure, height, body surface area, LV mass index, peripheral vascular resistance and antihypertensive medications in men. Taken together, these results suggest that both volume overload and abdominal obesity are related to AoR dilatation in hypertensive women, whereas AoR enlargement is associated more with inflammatory and myocardial growth-related parameters in hypertensive men with LV hypertrophy. Hypertension Research (2009) 32, 956-961; doi: 10.1038/hr.2009.134; published online 28 August 2009
Subject: aortic root
left ventricular hypertrophy
volume overload
Country: Inglaterra
Editor: Nature Publishing Group
Citation: Hypertension Research. Nature Publishing Group, v. 32, n. 11, n. 956, n. 961, 2009.
Rights: fechado
Identifier DOI: 10.1038/hr.2009.134
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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