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Type: Artigo de periódico
Title: Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus
Author: Kassuya, UAL
Leite, DFP
de Melo, LV
Rehder, VLG
Calixto, JB
Abstract: This study assessed the anti-inflammatory effect of the extracts and purified lignans obtained from Phyllanthus amarus. Given orally, the hexane extract (HE), the lignan-rich fraction (LRF), or the lignans phyltetralin, nirtetralin, niranthin, but not hypophyllanthin or phyllanthin, inhibited carrageenan (Cg)-induced paw oedema and neutrophil influx. The HE, the LRF or nirtetralin also inhibited the increase of IL1-beta tissue levels induced by Cg. Furthermore, bradykinin (BK)-, platelet activating factor (PAF)-and endothelin-1 (ET-1)-induced paw oedema were significantly inhibited by the HE or LRF while histamine and substance P-induced paw oedema were unaffected. Finally, nirtetralin or phyltetralin caused inhibition of paw oedema induced by PAF or ET-1. These results show that the HE, the LRF and the lignans niranthin, phyltetralin and nirtetralin exhibited marked anti-inflammatory properties and suggest that these lignans seem to be the main active principles responsible for the anti-inflammatory properties reported for the HE of P. amarus.
Subject: Phyllanthus amarus
anti-inflammatory action
paw oedema
Country: Alemanha
Editor: Georg Thieme Verlag Kg
Citation: Planta Medica. Georg Thieme Verlag Kg, v. 71, n. 8, n. 721, n. 726, 2005.
Rights: aberto
Identifier DOI: 10.1055/s-2005-871258
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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