Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Tissue-specific regulation of IRS-2/PI 3-kinase association in aged rats|
|Abstract:||We have examined the insulin-stimulated IRS-2 association with PI 3-kinase and the phosphorylation of AKT/PKB, which is functionally located downstream of the PI 3-kinase, in aged (obese) rats. The IRS-2 protein levels were similar in 2 and 20 month-old rats in both tissues, liver and muscle. There were reductions in insulin-induced IRS-2 tyrosine phosphorylation in liver and muscle, accompanied by a decrease in IRS-2/PI 3-kinase association and in AKT/PKB phosphorylation only in muscle tissue of aged rats. This regulation may be important in the altered glucose metabolism observed in aged (obese) rats.|
insulin receptor substrate-2
|Editor:||Walter De Gruyter & Co|
|Citation:||Biological Chemistry. Walter De Gruyter & Co, v. 381, n. 1, n. 75, n. 78, 2000.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.