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Type: Artigo de periódico
Title: Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects
Author: Pio-Magalhaes, JA
Ferreira-Sae, MC
Souza, FA
Grespan-Magossi, AM
Schreiber, R
Velloso, LA
Geloneze, B
Franchini, KG
Nadruz, W
Abstract: Aim: This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients. Methods: We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio. Results: Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDL-cholesterol levels was detected (r=-0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDL-cholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference. Conclusions: Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients. (J. Endocrinol. Invest. 34: 680-684, 2011) (C) 2011, Editrice Kurtis
Subject: Atorvastatin
hip circumference
Country: Itália
Editor: Editrice Kurtis S R L
Citation: Journal Of Endocrinological Investigation. Editrice Kurtis S R L, v. 34, n. 9, n. 680, n. 684, 2011.
Rights: fechado
Identifier DOI: 10.3275/7725
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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