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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInfluence of hemodilution on the renal blood flow autoregulation during acute expansion in ratspt_BR
dc.contributor.authorFranchini, KGpt_BR
unicamp.authorUniv Estadual Campinas, Fac Ciencias Med, Dept Clin Med, BR-13038970 Campinas, SP, Brazilpt_BR
dc.subjectrenal circulationpt_BR
dc.subjectblood rheologypt_BR
dc.subjectvolume expansionpt_BR
dc.subject.wosAcute Volume Expansionpt_BR
dc.subject.wosNitric-oxidept_BR
dc.subject.wosTubuloglomerular Feedbackpt_BR
dc.subject.wosGlomerular Ultrafiltrationpt_BR
dc.subject.wosSodium-excretionpt_BR
dc.subject.wosHemodynamicspt_BR
dc.subject.wosArteriolespt_BR
dc.subject.wosResistancept_BR
dc.subject.wosDependencept_BR
dc.subject.wosFiltrationpt_BR
dc.description.abstractAutoregulation of renal blood flow (RBP) was studied in rats that underwent equivalent blood volume expansion with saline (Sal; 5% body wt), 7% BSA solution (1.4% body wt), and reconstituted whole blood from donor rats (WBL; 1.4% body wt). Renal perfusion pressure (RPP) and renal neural reflexes were prevented by clamping RPP and sectioning the vagus, baro/chemoreceptor, and renal nerves. Sal and BSA expansion increased RBF by similar to 60%, whereas no effect was observed with WBL. RBF autoregulation was markedly attenuated after expansion with cell-free solutions, but no change occurred in WBL-expanded rats. Correction of the fall in hematocrit in Sal- and BSA-expanded rats restored RBF and its autoregulation to control levels. Expansion with Sal or BSA after inhibition of renal vascular tone with intrarenal infusion of papaverine still increased RBF and further changed the RBF-RPP relationship. These findings suggest that the hemodilution plays a central role in the reduction of renal vascular resistance and in the attenuation of the autoregulatory efficiency of renal circulation that accompany expansion with cell-free solutions.pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiologypt_BR
dc.relation.ispartofabbreviationAm. J. Physiol.-Regul. Integr. Comp. Physiol.pt_BR
dc.publisher.cityBethesdapt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Physiological Socpt_BR
dc.date.issued1999pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiology. Amer Physiological Soc, v. 277, n. 6, n. R1662, n. R1674, 1999.pt_BR
dc.language.isoenpt_BR
dc.description.volume277pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpageR1662pt_BR
dc.description.lastpageR1674pt_BR
dc.rightsembargopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0363-6119pt_BR
dc.identifier.wosidWOS:000084225100016pt_BR
dc.date.available2014-12-02T16:28:37Z
dc.date.available2015-11-26T16:37:24Z-
dc.date.accessioned2014-12-02T16:28:37Z
dc.date.accessioned2015-11-26T16:37:24Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:28:37Z (GMT). No. of bitstreams: 1 WOS000084225100016.pdf: 278809 bytes, checksum: ed33361d3bc4f3331be4642943102443 (MD5) Previous issue date: 1999en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:37:24Z (GMT). No. of bitstreams: 2 WOS000084225100016.pdf: 278809 bytes, checksum: ed33361d3bc4f3331be4642943102443 (MD5) WOS000084225100016.pdf.txt: 60034 bytes, checksum: b3ed9928fd6911e5b7a0f8f410c7b212 (MD5) Previous issue date: 1999en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80173pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/80173
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80173-
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