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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePostural Changes May Influence Popliteal Atherosclerosis by Modifying Local Circumferential Wall Tensionpt_BR
dc.contributor.authorGemignani, Tpt_BR
dc.contributor.authorMatos-Souza, JRpt_BR
dc.contributor.authorCoelho, ORpt_BR
dc.contributor.authorFranchini, KGpt_BR
dc.contributor.authorNadruz, Wpt_BR
unicamp.author.emailwilnj@fcm.unicamp.brpt_BR
unicamp.authorGemignani, Tiago Matos-Souza, Jose R. Coelho, Otavio R. Franchini, Kleber G. Nadruz, Wilson, Jr. Univ Estadual Campinas, Sch Med, Dept Internal Med, Campinas, SP, Brazilpt_BR
dc.subjectatherosclerosispt_BR
dc.subjectblood pressurept_BR
dc.subjectbody posturept_BR
dc.subjectcircumferential wall tensionpt_BR
dc.subjectIntima-media thicknesspt_BR
dc.subject.wosIntima-media Thicknesspt_BR
dc.subject.wosCardiovascular-diseasept_BR
dc.subject.wosHemodynamic Forcespt_BR
dc.subject.wosLower-extremitiespt_BR
dc.subject.wosPulse Pressurept_BR
dc.subject.wosCarotid-arterypt_BR
dc.subject.wosHypertensionpt_BR
dc.subject.wosResponsespt_BR
dc.subject.wosStresspt_BR
dc.subject.wosAdultspt_BR
dc.description.abstractAtherosclerosis of peripheral arteries typically affects vessels of the lower limbs, suggesting that local hemodynamic stimuli play a role in this process. Our study evaluated the effects of body postural changes on carotid and popliteal blood pressure, circumferential wall tension (CWT) and arterial strain, and investigated the relationship between such hemodynamic parameters and Intima-media thickness (IMT) of these arteries. One hundred seventeen nondiabetic, nonhypertensive, nonsmoker subjects (48 men and 69 women) were enrolled and had their blood pressure measured in the arm and calf in supine and orthostatic positions. Echo-doppler analysis evaluated the common carotid and popliteal arteries after blood pressure measurements, while CWT was calculated according to Laplace's law. The results showed that changing from supine to orthostatic posture Increased blood pressure and CWT In popliteal but not In carotid arteries. Partial correlation analysis adjusted for age and body mass index revealed no major relationship between IMT of the studied vessels and local blood pressure or arterial strain. Conversely, supine and orthostatic CWT exhibited comparable correlation coefficients with carotid IMT, while orthostatic CWT displayed a stronger relationship with popliteal IMT than with supine CWT. These results were confirmed by multiple linear regression analysis that Included age, sex, body mass Index, lipid fractions and glucose as independent variables. Overall, our results indicate that orthostatic CWT is a stronger hemodynamic predictor of popliteal IMT than supine CWT, suggesting that erectile posture may be a potential risk factor for popliteal atherosclerosis because it increases the local hemodynamic burden. (Hypertens Res 2008; 31: 2059-2064)pt
dc.relation.ispartofHypertension Researchpt_BR
dc.relation.ispartofabbreviationHypertens. Res.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherNature Publishing Grouppt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationHypertension Research. Nature Publishing Group, v. 31, n. 11, n. 2059, n. 2064, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume31pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage2059pt_BR
dc.description.lastpage2064pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0916-9636pt_BR
dc.identifier.wosidWOS:000262968800010pt_BR
dc.date.available2014-11-14T21:54:16Z
dc.date.available2015-11-26T17:17:27Z-
dc.date.accessioned2014-11-14T21:54:16Z
dc.date.accessioned2015-11-26T17:17:27Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:17:27Z (GMT). No. of bitstreams: 2 WOS000262968800010.pdf: 55830 bytes, checksum: 85651c9341d6a8d65986e762c657404c (MD5) WOS000262968800010.pdf.txt: 30191 bytes, checksum: 780092036119e703471d51836f4e62d8 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81109pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/81109
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81109-
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