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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOverexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progressionpt_BR
dc.contributor.authorHansson, Opt_BR
dc.contributor.authorNylandsted, Jpt_BR
dc.contributor.authorCastilho, RFpt_BR
dc.contributor.authorLeist, Mpt_BR
dc.contributor.authorJaattela, Mpt_BR
dc.contributor.authorBrundin, Ppt_BR
unicamp.authorLund Univ, Wallenberg Neurosci Ctr, Sect Neuronal Survival, Dept Physiol Sci, S-22184 Lund, Sweden Danish Canc Soc, Apoptosis Lab, Copenhagen, Denmark State Univ Campinas, Sch Med Sci, Dept Clin Pathol, Campinas, SP, Brazil H Lundbeck & Co AS, Sect Neuroprotect, DK-2500 Copenhagen, Denmarkpt_BR
dc.subjectHuntington's diseasept_BR
dc.subjectinclusionpt_BR
dc.subjectheat shock protein 70 (Hsp70)pt_BR
dc.subjectchaperonept_BR
dc.subjecttransgenicpt_BR
dc.subjectmousept_BR
dc.subject.wosNeuronal Intranuclear Inclusionspt_BR
dc.subject.wosTransgenic Mouse Modelpt_BR
dc.subject.wosN-terminal Huntingtinpt_BR
dc.subject.wosPolyglutamine Expansionpt_BR
dc.subject.wosChaperone Suppressionpt_BR
dc.subject.wosMolecular Chaperonespt_BR
dc.subject.wosAggregate Formationpt_BR
dc.subject.wosCellular Toxicitypt_BR
dc.subject.wosSca1 Micept_BR
dc.subject.wosHsp70pt_BR
dc.description.abstractHuntington's disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been shown to reduce polyglutamine-induced toxicity. To investigate if overexpression of Hsp70 can affect disease progression in a mouse model of HD, we crossed R6/2 mice, expressing exon I of the HD gene with an expanded CAG repeat, with mice overexpressing Hsp70 (both types of transgenic mice were of the CBAxC57BL/6 strain). The resulting R6/2-Hsp70 transgenics exhibited 5- to 15-fold increases in Hsp70 expression in neocortical, hippocampal and basal ganglia regions. This correlated with a delayed loss of body weight compared to R6/2 mice. However, the number or size of nuclear inclusions, the loss of brain weight, reduction of striatal volume, reduction in size of striatal projection neurons, downregulation of DARPP-32, development of paw clasping phenotype and early death of the mice were not affected by Hsp70 overexpression. Interestingly, the polyglutamine protein affected the potential rescuing agent, because in older R6/2-Hsp70 mice a large proportion of the Hsp70 protein was sequestrated in nuclear inclusions. (C) 2002 Elsevier Science B.V. All rights reserved.pt
dc.relation.ispartofBrain Researchpt_BR
dc.relation.ispartofabbreviationBrain Res.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculationAPR 25pt_BR
dc.identifier.citationBrain Research. Elsevier Science Bv, v. 970, n. 41671, n. 47, n. 57, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume970pt_BR
dc.description.issuenumber41671pt_BR
dc.description.firstpage47pt_BR
dc.description.lastpage57pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0006-8993pt_BR
dc.identifier.wosidWOS:000182790200005pt_BR
dc.identifier.doi10.1016/S0006-8993(02)04275-0pt_BR
dc.date.available2014-11-14T03:51:09Z
dc.date.available2015-11-26T17:13:06Z-
dc.date.accessioned2014-11-14T03:51:09Z
dc.date.accessioned2015-11-26T17:13:06Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:13:06Z (GMT). No. of bitstreams: 2 WOS000182790200005.pdf: 1511281 bytes, checksum: 060af5d27f3505faa9df6e75c4b69b31 (MD5) WOS000182790200005.pdf.txt: 42079 bytes, checksum: 137de344b089651c5b3fe0fdd22a8fb7 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81540pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/81540
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81540-
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