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Type: Artigo de periódico
Title: Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects
Author: Paim, LR
Schreiber, R
Matos-Souza, JR
Silva, AA
Campos, LF
Azevedo, ER
Alonso, K
de Rossi, G
Etchebehere, M
Gorla, JI
Cliquet, A
Nadruz, W
Abstract: Objective: Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role of physical activity in this regard. Methods: We studied 42 men with chronic (>= 2 years) SCI [18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay. Results: Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied subjects were statistically similar. Conversely, S-SCI subjects exhibited higher IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. Results of bivariate correlation analysis including all injured subjects showed that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the presence or not of physical activity and age showed that OxLDL was associated with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with IMT/diameter ratio in SCI individuals. Conclusions: Plasmatic OxLDL and MMP-8 levels are associated with carotid atherosclerosis and there is an interaction among physical inactivity, atherosclerosis and OxLDL in SCI individuals. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Subject: Paraplegia
Intima-media thickness
Oxidized LDL
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Atherosclerosis. Elsevier Ireland Ltd, v. 231, n. 2, n. 341, n. 345, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.atherosclerosis.2013.10.005
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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