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Type: Artigo de periódico
Title: One-pot synthesis of organophosphate monoesters from alcohols
Author: Lira, LM
Vasilev, D
Pilli, RA
Wessjohann, LA
Abstract: A one-pot procedure for the phosphorylation of alcohols provides the corresponding phosphate monoesters in improved yields. The protocol features the use of tetrabutylammonium hydrogen phosphate and trichloroacetonitrile, followed by purification of the crude product by flash chromatography on silica gel. The final step, cation exchange chromatography, affords the organophosphates as ammonium salts that are usually required for biochemical applications. The mechanism appears to be phosphate rather than alcohol activation by trichloroacetonitrile. (c) 2013 Elsevier Ltd. All rights reserved.
Subject: Alcohol
One-pot synthesis
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 54, n. 13, n. 1690, n. 1692, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2013.01.059
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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