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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePhotodynamic Antimicrobial Effects Of Bis-indole Alkaloid Indigo From Indigofera Truxillensis Kunth (leguminosae)pt_BR
dc.contributor.authorAndreazza N.L.pt_BR
dc.contributor.authorde Lourenco C.C.pt_BR
dc.contributor.authorStefanello M.E.A.pt_BR
dc.contributor.authorAtvars T.D.Z.pt_BR
dc.contributor.authorSalvador M.J.pt_BR
unicamp.authorAndreazza, N.L., Instituto de Biologia, Departamento de Biologia Vegetal, PPG BTPB e PPG BV, Universidade Estadual de Campinas (UNICAMP)Campinas, SP, Brazilpt_BR
unicamp.authorde Lourenço, C.C., Instituto de Biologia, Departamento de Biologia Vegetal, PPG BTPB e PPG BV, Universidade Estadual de Campinas (UNICAMP)Campinas, SP, Brazilpt_BR
unicamp.authorAtvars, T.D.Z., Instituto de Química, Universidade Estadual de Campinas (UNICAMP)Campinas, SP, Brazilpt_BR
unicamp.authorSalvador, M.J., Instituto de Biologia, Departamento de Biologia Vegetal, PPG BTPB e PPG BV, Universidade Estadual de Campinas (UNICAMP)Campinas, SP, Brazilpt_BR
unicamp.author.externalStefanello, M.É.A., Departamento de Química, Universidade Federal do Paraná (UFPR)Curitiba, PR, Brazilpt
dc.description.abstractMultidrug-resistant microbial infections represent an exponentially growing problem affecting communities worldwide. Photodynamic therapy is a promising treatment based on the combination of light, oxygen, and a photosensitizer that leads to reactive oxygen species production, such as superoxide (type I mechanism) and singlet oxygen (type II mechanism) that cause massive oxidative damage and consequently the host cell death. Indigofera genus has gained considerable interest due its mutagenic, cytotoxic, and genotoxic activity. Therefore, this study was undertaken to investigate the effect of crude extracts, alkaloidal fraction, and isolated substance derived from Indigofera truxillensis in photodynamic antimicrobial chemotherapy on the viability of bacteria and yeast and evaluation of mechanisms involved. Our results showed that all samples resulted in microbial photoactivation in subinhibitory concentration, with indigo alkaloid presenting a predominant photodynamic action through type I mechanism. The use of CaCl2 and MgCl2 as cell permeabilizing additives also increased gram-negative bacteria susceptibility to indigo.en
dc.relation.ispartofLasers in Medical Sciencept_BR
dc.publisherSpringer-Verlag London Ltdpt_BR
dc.date.issued2015pt_BR
dc.identifier.citationLasers In Medical Science. Springer-verlag London Ltd, v. , n. , p. - , 2015.pt_BR
dc.language.isoenpt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn2688921pt_BR
dc.identifier.doi10.1007/s10103-015-1735-4pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84924567197&partnerID=40&md5=475147010c3d6141c868fc7e906fe7d9pt_BR
dc.date.available2015-06-25T12:51:05Z
dc.date.available2015-11-26T14:58:01Z-
dc.date.accessioned2015-06-25T12:51:05Z
dc.date.accessioned2015-11-26T14:58:01Z-
dc.description.provenanceMade available in DSpace on 2015-06-25T12:51:05Z (GMT). No. of bitstreams: 1 2-s2.0-84924567197.pdf: 747578 bytes, checksum: 0498fb090385cb544429a50f4b9168d6 (MD5) Previous issue date: 2015en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:58:01Z (GMT). No. of bitstreams: 2 2-s2.0-84924567197.pdf: 747578 bytes, checksum: 0498fb090385cb544429a50f4b9168d6 (MD5) 2-s2.0-84924567197.pdf.txt: 43953 bytes, checksum: 6d40fa6887a04e295fd00278afecd884 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/85208
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85208-
dc.identifier.idScopus2-s2.0-84924567197pt_BR
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