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Type: Artigo de periódico
Title: Bioactivity And Chemical Composition Of The Essential Oil From The Leaves Of Guatteria Australis
Author: Siqueira C.A.T.
Serain A.F.
Pascoal A.C.R.F.
Andreazza N.L.
de Lourenco C.C.
Gois Ruiz A.L.T.
de Carvalho J.E.
de Souza A.C.O.
Tonini Mesquita J.
Tempone A.G.
Salvador M.J.
Abstract: Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.
Editor: Taylor and Francis Ltd.
Citation: Natural Product Research. Taylor And Francis Ltd., v. , n. , p. - , 2015.
Rights: fechado
Identifier DOI: 10.1080/14786419.2015.1015017
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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