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Type: Artigo de periódico
Title: Two New Hydronaphthoquinones From Sinningia Aggregata (gesneriaceae) And Cytotoxic Activity Of Aggregatin D
Author: Verdan M.H.
De Souza L.M.
De Carvalho J.E.
Vendramini Costa D.B.
Salvador M.J.
Barison A.
Stefanello M.E.A.
Abstract: Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (KER-GAWL.) WIEHLER (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2-methylanthraquinone (5), icosyl ferulate (6), pustuline (7), 1,6-dihydroxy-2-methylanthranquinone (8), 6-hydroxy-2-methylanthraquinone (9), 7-hydroxy-2-methylanthraquinone (10), tyrosol (11), halleridone (12), calceolarioside B (13), and cornoside (14). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4, and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC-62, 786-0 and OVCAR-3 cell lines, with IC50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non-cancer cell line HaCat (human keratinocyte).
Editor: Wiley-VCH Verlag
Citation: Chemistry And Biodiversity. Wiley-vch Verlag, v. 12, n. 1, p. 148 - 152, 2015.
Rights: fechado
Identifier DOI: 10.1002/cbdv.201400281
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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