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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleIn Vitro, In Vivo And In Silico Analysis Of The Anticancer And Estrogen-like Activity Of Guava Leaf Extractspt_BR
dc.contributor.authorRizzo L.Y.pt_BR
dc.contributor.authorLongato G.B.pt_BR
dc.contributor.authorRuiz A.Lt.G.pt_BR
dc.contributor.authorTinti S.V.pt_BR
dc.contributor.authorPossenti A.pt_BR
dc.contributor.authorVendramini-Costa D.B.pt_BR
dc.contributor.authorSartoratto A.pt_BR
dc.contributor.authorFigueira G.M.pt_BR
dc.contributor.authorSilva F.L.N.pt_BR
dc.contributor.authorEberlin M.N.pt_BR
dc.contributor.authorSouza T.A.C.B.pt_BR
dc.contributor.authorMurakami M.T.pt_BR
dc.contributor.authorRizzo E.pt_BR
dc.contributor.authorFoglio M.A.pt_BR
dc.contributor.authorKiessling F.pt_BR
dc.contributor.authorLammers T.pt_BR
dc.contributor.authorCarvalho J.E.pt_BR
unicamp.authorRizzo, L.Y., Department of Experimental Molecular Imaging (ExMI), RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany, Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorLongato, G.B., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorRuiz, A.Lt.G., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorTinti, S.V., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorPossenti, A., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorVendramini-Costa, D.B., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorSartoratto, A., Divisão de Química Orgânica e Farmacêutica, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorFigueira, G.M., Divisão de Agrotecnologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorSilva, F.L.N., Laboratório ThoMSon de Espectrometria de Massas, Instituto de Química, Universidade Estadual de Campinas - Unicamp, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorEberlin, M.N., Laboratório ThoMSon de Espectrometria de Massas, Instituto de Química, Universidade Estadual de Campinas - Unicamp, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorFoglio, M.A., Divisão de Fitoquímica, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas-Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorCarvalho, J.E., Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), Universidade Estadual de Campinas - Unicamp, P.O.Box 6171, 13083-970, Campinas, SP, Brazilpt_BR
unicamp.author.externalSouza, T.A.C.B., Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, 13083-970, Campinas, SP, Brazilpt
unicamp.author.externalMurakami, M.T., Laboratório Nacional de Biociências, Centro Nacional de Pesquisas em Energia e Materiais, 13083-970, Campinas, SP, Brazilpt
unicamp.author.externalRizzo, E., Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais - UFMG, P.O. Box 486, 30161-970, Belo Horizonte, MG, Brazilpt
unicamp.author.externalKiessling, F., Department of Experimental Molecular Imaging (ExMI), RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germanypt
unicamp.author.externalLammers, T., Department of Experimental Molecular Imaging (ExMI), RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germanypt
dc.description.abstractAnticancer drug research based on natural compounds enabled the discovery of many drugs currently used in cancer therapy. Here, we report the in vitro, in vivo and in silico anticancer and estrogen-like activity of Psidium guajava L. (guava) extracts and enriched mixture containing the meroterpenes guajadial, psidial A and psiguadial A and B. All samples were evaluated in vitro for anticancer activity against nine human cancer lines: K562 (leukemia), MCF7 (breast), NCI/ADR-RES (resistant ovarian cancer), NCI-H460 (lung), UACC-62 (melanoma), PC-3 (prostate), HT-29 (colon), OVCAR-3 (ovarian) and 786-0 (kidney). Psidium guajava's active compounds displayed similar physicochemical properties to estradiol and tamoxifen, as in silico molecular docking studies demonstrated that they fit into the estrogen receptors (ERs). The meroterpene-enriched fraction was also evaluated in vivo in a Solid Ehrlich murine breast adenocarcinoma model, and showed to be highly effective in inhibiting tumor growth, also demonstrating uterus increase in comparison to negative controls. The ability of guajadial, psidial A and psiguadials A and B to reduce tumor growth and stimulate uterus proliferation, as well as their in silico docking similarity to tamoxifen, suggest that these compounds may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy. © 2014 Bentham Science Publishers.en
dc.relation.ispartofCurrent Medicinal Chemistrypt_BR
dc.publisherBentham Science Publishers B.V.pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationCurrent Medicinal Chemistry. Bentham Science Publishers B.v., v. 21, n. 20, p. 2322 - 2330, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber20pt_BR
dc.description.firstpage2322pt_BR
dc.description.lastpage2330pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn9298673pt_BR
dc.identifier.doi10.2174/0929867321666140120120031pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84900335825&partnerID=40&md5=9a2a1211c065326de41ba5a72ba9d5efpt_BR
dc.date.available2015-06-25T17:50:05Z
dc.date.available2015-11-26T15:28:52Z-
dc.date.accessioned2015-06-25T17:50:05Z
dc.date.accessioned2015-11-26T15:28:52Z-
dc.description.provenanceMade available in DSpace on 2015-06-25T17:50:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T15:28:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/85763
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85763-
dc.identifier.idScopus2-s2.0-84900335825pt_BR
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