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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Hypothesis For The Anti-inflammatory And Mechanotransduction Molecular Mechanisms Underlying Acupuncture Tendon Healing.pt_BR
dc.contributor.authorAlmeida M.S.pt_BR
dc.contributor.authorGuerra F.R.pt_BR
dc.contributor.authorde Oliveira L.P.pt_BR
dc.contributor.authorVieira C.P.pt_BR
dc.contributor.authorPimentel E.R.pt_BR
unicamp.authorAlmeida, M.S., Department of Functional and Structural Biology, Institute of Biology, University of Campinas-UNICAMP, , Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalGuerra, F.R.pt
unicamp.author.externalde Oliveira, L.P.pt
unicamp.author.externalVieira, C.P.pt
unicamp.author.externalPimentel, E.R.pt
dc.description.abstractA previous study demonstrated that acupuncture increases the synthesis and reorganisation of collagen molecules in rat tendons after injury. Clinical studies have shown that acupuncture improves pain and functional activity in patients with tendinopathy. However, the molecular mechanisms underlying these effects are unknown. Recent studies have shown that acupuncture can modulate both anti-inflammatory (AI) and mechanotransduction (MT) molecular pathways. Moreover, the modulation of these pathways can increase type I collagen synthesis, which is the main factor that influences tendon biomechanical properties. Our hypothesis is that acupuncture increases synthesis and subsequent reorganisation of type I collagen during tendon healing by concomitant modulation of the Toll-like receptor-nuclear factor-κB AI pathway, the mitogen-activated protein kinases pathway and the Rho/Rac-F-actin MT pathway. Increased collagen synthesis and reorganisation requires that at least one acupoint is anatomically connected with the site of the injury because of the local tenoblast MT mechanism. Confirmation of this hypothesis will increase the knowledge of acupuncture modulation of the previously mentioned molecular pathways, and such confirmation may also help to establish the relationships between the different types of acupuncture needle stimulation and the influence of acupuncture stimuli on pathway activity levels. In addition, the downstream therapeutic effects of acupuncture therapy may be established. This hypothesis can be verified in a rat tendon healing model, and subsequent clinical protocols for tendon healing can be developed and evaluated as standalone therapies or as a component of a combination therapy.en
dc.relation.ispartofAcupuncture in medicine : journal of the British Medical Acupuncture Societypt_BR
dc.date.issued2014pt_BR
dc.identifier.citationAcupuncture In Medicine : Journal Of The British Medical Acupuncture Society. , v. 32, n. 2, p. 178 - 182, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage178pt_BR
dc.description.lastpage182pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn17599873pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84908650847&partnerID=40&md5=006caec37d83a798c31f4157403ba8capt_BR
dc.date.available2015-06-25T17:54:20Z
dc.date.available2015-11-26T14:32:41Z-
dc.date.accessioned2015-06-25T17:54:20Z
dc.date.accessioned2015-11-26T14:32:41Z-
dc.description.provenanceMade available in DSpace on 2015-06-25T17:54:20Z (GMT). No. of bitstreams: 1 2-s2.0-84908650847.pdf: 215675 bytes, checksum: 0625d4af3da4afb32b2892d4ba04c131 (MD5) Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:32:41Z (GMT). No. of bitstreams: 2 2-s2.0-84908650847.pdf: 215675 bytes, checksum: 0625d4af3da4afb32b2892d4ba04c131 (MD5) 2-s2.0-84908650847.pdf.txt: 27314 bytes, checksum: aa4fdcc297b0cdb9e955ab451a0a423e (MD5) Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/86661
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86661-
dc.identifier.idScopus2-s2.0-84908650847pt_BR
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