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Type: Artigo de periódico
Title: Apoliprotein E Genotype Is Associated With Apoliprotein B Plasma Levels But Not With Coronary Calcium Score In Very Elderly Individuals In Primary Care Setting
Author: Henriques A.D.
Tonet-Furioso A.C.
Machado-Silva W.
Freitas W.M.
Quaglia L.A.
Santos S.N.
Cordova C.
Sposito A.C.
Nobrega O.T.
Abstract: Background: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. Aim: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. Methods: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. Results: When non- ε4 carriers were compared with ε4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. Conclusion: The study suggests a possible atherogenic role of the ε4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting. © 2014 Elsevier B.V.
Citation: Gene. , v. 539, n. 2, p. 275 - 278, 2014.
Rights: fechado
Identifier DOI: 10.1016/j.gene.2014.01.077
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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