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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAdvantage Of Guaraná (paullinia Cupana Mart.) Supplementation On Cadmium-induced Damages In Testis Of Adult Wistar Ratspt_BR
dc.contributor.authorLeite R.P.pt_BR
dc.contributor.authorPredes F.S.pt_BR
dc.contributor.authorMonteiro J.C.pt_BR
dc.contributor.authorFreitas K.M.pt_BR
dc.contributor.authorWada R.S.pt_BR
dc.contributor.authorDolder H.pt_BR
unicamp.authorLeite, R.P., Department of Cell Biology, Institute of Biology, UNICAMP, São Paulo, Brazilpt_BR
unicamp.authorPredes, F.S., Department of Cell Biology, Institute of Biology, UNICAMP, São Paulo, Brazilpt_BR
unicamp.authorMonteiro, J.C., Department of Cell Biology, Institute of Biology, UNICAMP, São Paulo, Brazilpt_BR
unicamp.authorFreitas, K.M., Department of Cell Biology, Institute of Biology, UNICAMP, São Paulo, Brazilpt_BR
unicamp.authorWada, R.S., Piracicaba Dental School (FOP), UNICAMP, São Paulo, Brazilpt_BR
unicamp.authorDolder, H., Department of Cell Biology, Institute of Biology, UNICAMP, São Paulo, Brazilpt_BR
dc.description.abstractPaullinia cupana is an Amazonian bush whose seeds have long been used in folk medicine. However, most of the therapeutic properties attributed to this plant are broad and nonspecific, although an antioxidant activity has been reported. On the other hand, cadmium is a heavy metal known for increasing free radicals, hence resulting in cellular oxidative damages. This study was designed to evaluate whether Paullinia cupana is able to reduce cadmium-induced morphological impairment in Wistar rat testis. Adult male Wistar rats 110 days old were ip injected with cadmium (1.15 mg/kg BW [body weight]) and subsequently treated with P. cupana during 56 days. Furthermore, groups receiving either P. cupana extract or cadmium are mentioned. After the treatment period, testis samples were subjected to histological and stereological analyses. Moderate to severe testicular impairments were shown by the animals exposed to cadmium. However, the animals supplemented with P. cupana after cadmium exposure showed a significant decrease in the proportion of damaged seminiferous tubules. Also, P. cupana supplementation was effective in maintaining the number of Leydig cells per testis in the animals exposed to cadmium. In conclusion, P. cupana supplementation was partially efficient in preventing cadmium from damaging the testis of adult Wistar rats. © 2013 by The Author(s).en
dc.relation.ispartofToxicologic Pathologypt_BR
dc.date.issued2013pt_BR
dc.identifier.citationToxicologic Pathology. , v. 41, n. 1, p. 73 - 79, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume41pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage73pt_BR
dc.description.lastpage79pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn1926233pt_BR
dc.identifier.doi10.1177/0192623312447541pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84871663535&partnerID=40&md5=8a83093d5df401b294aceb10b899e83dpt_BR
dc.date.available2015-06-25T19:16:02Z
dc.date.available2015-11-26T15:14:04Z-
dc.date.accessioned2015-06-25T19:16:02Z
dc.date.accessioned2015-11-26T15:14:04Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T15:14:04Z (GMT). No. of bitstreams: 2 2-s2.0-84871663535.pdf: 1003673 bytes, checksum: c2d5cb49dbb9cfc04900b6df2ef1c082 (MD5) 2-s2.0-84871663535.pdf.txt: 28357 bytes, checksum: 123fa177f8f9aae801e824f84c686c0e (MD5) Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/89391
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89391-
dc.identifier.idScopus2-s2.0-84871663535pt_BR
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