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Type: Artigo de periódico
Title: Cytotoxic Activity Of Guettarda Pohliana Müll. Arg. (rubiaceae)
Author: De Oliveira P.R.N.
Testa G.
Medina R.P.
De Oliveira C.M.A.
Kato L.
Da Silva C.C.
De Carvalho J.E.
Santin S.M.O.
Abstract: The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCIADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI50 values being lower than 1μgmL-1. Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude. The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin. © 2013 Taylor & Franci.
Citation: Natural Product Research. , v. 27, n. 18, p. 1677 - 1681, 2013.
Rights: fechado
Identifier DOI: 10.1080/14786419.2012.761616
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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