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Type: Artigo de periódico
Title: Synthesis, Antitumor And Antimicrobial Activity Of Novel 1-substituted Phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] β-carboline Derivatives
Author: Savariz F.C.
Formagio A.S.N.
Barbosa V.A.
Foglio M.A.
De Carvalho J.E.
Duarte M.C.T.
Dias Filhoc B.P.
Sarragiotto M.H.
Abstract: With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized β-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (% ABS) data. © 2010 Sociedade Brasileira de Química.
Citation: Journal Of The Brazilian Chemical Society. , v. 21, n. 2, p. 288 - 298, 2010.
Rights: aberto
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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