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Type: Artigo de periódico
Title: Effect Of 6α,7β-dihydroxyvouacapan-17β-oic Acid And Its Lactone Derivatives On The Growth Of Human Cancer Cells
Author: Euzebio F.P.G.
dos Santos F.J.L.
Pilo-Veloso D.
Ruiz A.L.T.G.
de Carvalho J.E.
Ferreira-Alves D.L.
Fatima A.d.
Abstract: The furanditerpene 6α,7β-dihydroxyvouacapan-17β-oic acid (1) is a natural product biosynthesized by some species from the genus Pterodon (Leguminosae). This secondary metabolite has multiple biological activities that include anti-inflammatory, analgesic, plant growth regulatory, anti-edematogenic, photosystem II inhibitory and photosynthesis uncoupler, and antifungal properties. However, few studies on the antiproliferative profile of compound 1 and/or its derivatives have been reported up to date. Here, we describe the isolation of compound 1 from hexane extract of P. polygalaeflorus fruits as well as the semisynthesis of three lactone derivatives: 6α-hydroxyvouacapan-7β,17β-lactone (2), 6α-acetoxyvouacapan-7β,17β-lactone (3), and 6-oxovouacapan-7β,17β-lactone (4). Additionally, antiproliferative activity of these compounds against nine human cancer cell lines was investigated. Our results revealed that 6α-hydroxyvouacapan-7β,17β-lactone (2) was the most potent furanditerpene against all cancer cell lines studied. The presence of non-substituted hydroxyl group at C-6 and the presence of 7β,17β-lactone ring are important for the antiproliferative activity of these compounds. © 2009 Elsevier Inc. All rights reserved.
Citation: Bioorganic Chemistry. , v. 37, n. 3, p. 96 - 100, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.bioorg.2009.03.004
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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