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Type: Artigo de periódico
Title: A New Polyacetylene From Vernonia Scorpioides (lam.) Pers. (asteraceae) And Its In Vitro Antitumoral Activity
Author: Buskuhl H.
Freitas R.A.
Monache F.D.
Barison A.
Campos F.R.
Corilo Y.E.
Eberlin M.N.
Biavatti M.W.
Abstract: The dichloromethane fraction obtained from hydroalcoholic crude extract of leaves and flowers of Vernonia scorpioides (Asteraceae) was investigated, resulting in the isolation and structure elucidation of a new polyacetylene namely 5-octa-2,4,6-triynyl-furan-2(5H)-one. The structure of the isolated compound was determined based on IR, NMR (1D and 2D) and MS spectrometric data. The antitumor potential, including cytotoxicity to tumor cells and genotoxicity, was investigated. The results suggest that apoptotic cell death may have occurred, at least in part, via a caspase-dependent mechanism. © 2009 Sociedade Brasileira de Química.
Citation: Journal Of The Brazilian Chemical Society. , v. 20, n. 7, p. 1327 - 1333, 2009.
Rights: aberto
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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