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Type: Artigo de periódico
Title: Protective Effect Of Bovine Milk Whey Protein Concentrate On The Ulceratire Lesions Caused By Subcutaneous Administration Of Indomethacin
Author: Rosaneli C.F.
Bighetti A.E.
Antonio M.A.
Carvalho J.E.
Sgarbieri V.C.
Abstract: The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4°C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P < .01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P > .05) compared with saline (negative control).
Citation: Journal Of Medicinal Food. , v. 7, n. 3, p. 309 - 314, 2004.
Rights: fechado
Identifier DOI: 10.1089/jmf.2004.7.309
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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