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dc.typeArtigo de periódicopt_BR
dc.titleAntioxidant Capacity And Pharmacologic Screening Of Crude Extracts Of Byrsonima Crassifolia And Inga Edulis Leaves [capacidade Antioxidante E Triagem Farmacológica De Extratos Brutos De Folhas De Byrsonima Crassifolia E De Inga Edulis]pt_BR
dc.contributor.authorPompeu D.R.pt_BR
dc.contributor.authorRogez H.pt_BR
dc.contributor.authorMonteiro K.M.pt_BR
dc.contributor.authorTinti S.V.pt_BR
dc.contributor.authorCarvalho J.E.pt_BR
unicamp.authorMonteiro, K.M., Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agronômicas, Universidade Estadual de Campinas, Brazilpt_BR
unicamp.authorTinti, S.V., Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agronômicas, Universidade Estadual de Campinas, Brazilpt_BR
unicamp.authorCarvalho, J.E., Centro de Pluridisciplinar de Pesquisas Químicas, Biológicas e Agronômicas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazilpt_BR, D.R., Departamento de Tecnologia de Alimentos, Centro de Ciências Naturais e Tecnologia, Universidade do Estado do Pará, Centro de Valorização Agroalimentar de Compostos Bioativos da Amazônia, Brazilpt, H., Faculdade de Engenharia de Alimentos, Universidade Federal do Pará, Centro de Valorização Agroalimentar de Compostos Bioativos da Amazônia, Brazilpt
dc.description.abstractIn order to evaluate the effect of two Amazonian species on chronic diseases linked with the oxidative processes, we performed antioxidant capacity analyses (Oxygen Radical Absorbance Capacity - ORAC and Folin-Ciocalteu - PT assays) and pharmacological effects in vitro (antiproliferative effect) and in vivo (antinociceptive, antiinflammatory, antiulcerogenic effects) for ethanolic extracts (65:35; v/v; ethanol: water) from Byrsonima crassifolia (BC) and Inga edulis (IE) leaves. Both BC and IE extracts showed high ORAC values (1,422 and 694 mmol of Trolox equivalent/g of dry leaf, respectively) and high PT contents (35.93 and 24.50 mg gallic acid equivalent g-1 dry leaf, respectively). The ORAC values had no correlation with PT, suggesting the presence of other chemical groups in the antioxidant activity value. The two extracts did not present significant antiproliferative activity on nine lines of human tumor cells, and cytotoxic effect was detected only at the highest concentration. The antinociceptive effect was investigated using the hot plate test, and IE extract presented a longer latency (P < 0.05) 30 and 60 min after oral administration. The antiinflammatory activity was only observed at the highest concentration, suggesting that the antinociceptive effect observed was not due to the antiinflammatory effect. The extracts of both species reduced the ulcerative lesions produced by ethanol up to 84% (P < 0.05), suggesting a relation with the antioxidant capacity. More studies are necessary to elucidate the mechanisms of action involved on antiulcerative effects.en
dc.relation.ispartofActa Amazonicapt_BR
dc.identifier.citationActa Amazonica. , v. 42, n. 1, p. 165 - 172, 2012.pt_BR
dc.description.provenanceMade available in DSpace on 2015-06-26T20:28:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:24:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
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