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Type: Artigo de periódico
Title: Chemical Study Of Sinningia Allagophylla Guided By Antiproliferative Activity Assays [estudo Químico De Sinningia Allagophylla Guiado Por Testes De Atividade Antiproliferativa]
Author: Riva D.
Barison A.
Stefanello M.E.A.
Poliquesi C.B.
Ruiz A.L.T.G.
De Carvalho J.E.
Salvador M.J.
Abstract: Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.
Citation: Quimica Nova. , v. 35, n. 5, p. 974 - 977, 2012.
Rights: aberto
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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