Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96730
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleChemical Study Of Sinningia Allagophylla Guided By Antiproliferative Activity Assays [estudo Químico De Sinningia Allagophylla Guiado Por Testes De Atividade Antiproliferativa]pt_BR
dc.contributor.authorRiva D.pt_BR
dc.contributor.authorBarison A.pt_BR
dc.contributor.authorStefanello M.E.A.pt_BR
dc.contributor.authorPoliquesi C.B.pt_BR
dc.contributor.authorRuiz A.L.T.G.pt_BR
dc.contributor.authorDe Carvalho J.E.pt_BR
dc.contributor.authorSalvador M.J.pt_BR
unicamp.authorRuiz, A.L.T.G., Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Universidade Estadual de Campinas, 13083-970 Campinas-SP, Brazilpt_BR
unicamp.authorDe Carvalho, J.E., Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Universidade Estadual de Campinas, 13083-970 Campinas-SP, Brazilpt_BR
unicamp.authorSalvador, M.J., Curso de Farmácia, Instituto de Biologia, Universidade Estadual de Campinas, 13083-970 Campinas-SP, Brazilpt_BR
unicamp.author.externalRiva, D., Departamento de Química, Universidade Federal do Paraná, 81530-900 Curitiba-PR, Brazilpt
unicamp.author.externalBarison, A., Departamento de Química, Universidade Federal do Paraná, 81530-900 Curitiba-PR, Brazilpt
unicamp.author.externalStefanello, M.E.A., Departamento de Química, Universidade Federal do Paraná, 81530-900 Curitiba-PR, Brazilpt
unicamp.author.externalPoliquesi, C.B., Museu Botânico Municipal, Secretaria Municipal do Meio Ambiente, 80001-970 Curitiba-PR, Brazilpt
dc.description.abstractActivity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.en
dc.relation.ispartofQuimica Novapt_BR
dc.date.issued2012pt_BR
dc.identifier.citationQuimica Nova. , v. 35, n. 5, p. 974 - 977, 2012.pt_BR
dc.language.isoptpt_BR
dc.description.volume35pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage974pt_BR
dc.description.lastpage977pt_BR
dc.rightsabertopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn1004042pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84864193817&partnerID=40&md5=8a7244b666477ae768bdf17cebd794b8pt_BR
dc.date.available2015-06-26T20:28:44Z
dc.date.available2015-11-26T14:24:43Z-
dc.date.accessioned2015-06-26T20:28:44Z
dc.date.accessioned2015-11-26T14:24:43Z-
dc.description.provenanceMade available in DSpace on 2015-06-26T20:28:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:24:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/96730
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96730-
dc.identifier.idScopus2-s2.0-84864193817pt_BR
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