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|Type:||Artigo de periódico|
|Title:||Alterations In The Achilles Tendon After Inflammation In Surrounding Tissue|
da Re Guerra F.
de Oliveira L.P.
dos Santos de Almeida M.
|Abstract:||Objective: To analyze the characteristics of the Achilles tendon of rats after induction of localized inflammation in the rat paw. Methods: In our study three groups were used: inflamed group with carrageenan in rat paw (G1); saline group (G2) and control group (G3). After 4 hours the animals were euthanized and the Achilles tendon removed. Results: No significant differences were observed in the analysis of non-collagenous proteins, glycosaminoglycans and hydroxyproline in the groups but a tendency of reduction was verified in G1. As regards the organization of collagen molecules, no differences were observed between groups. With respect to MMPs activity, a stronger presence of the active isoform of MMP-2 in G1 was observed, suggesting that the remodeling was occurring. Conclusion: Thus, we conclude that the inflammatory process in rat paw may affect the remodeling of tendons located near the inflamed site.|
|Citation:||Acta Ortopedica Brasileira. , v. 20, n. 5, p. 266 - 269, 2012.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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