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Type: Artigo de periódico
Title: Alterations In The Achilles Tendon After Inflammation In Surrounding Tissue
Author: Vieira C.P.
da Re Guerra F.
de Oliveira L.P.
dos Santos de Almeida M.
Pimentel E.R.
Abstract: Objective: To analyze the characteristics of the Achilles tendon of rats after induction of localized inflammation in the rat paw. Methods: In our study three groups were used: inflamed group with carrageenan in rat paw (G1); saline group (G2) and control group (G3). After 4 hours the animals were euthanized and the Achilles tendon removed. Results: No significant differences were observed in the analysis of non-collagenous proteins, glycosaminoglycans and hydroxyproline in the groups but a tendency of reduction was verified in G1. As regards the organization of collagen molecules, no differences were observed between groups. With respect to MMPs activity, a stronger presence of the active isoform of MMP-2 in G1 was observed, suggesting that the remodeling was occurring. Conclusion: Thus, we conclude that the inflammatory process in rat paw may affect the remodeling of tendons located near the inflamed site.
Citation: Acta Ortopedica Brasileira. , v. 20, n. 5, p. 266 - 269, 2012.
Rights: aberto
Identifier DOI: 10.1590/S1413-78522012000500004
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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