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Type: Artigo de periódico
Title: Synthesis And Evaluation Of New β-carboline-3-(4-benzylidene)- 4h-oxazol-5-one Derivatives As Antitumor Agents
Author: Savariz F.C.
Foglio M.A.
De Carvalho J.E.
Ruiz A.L.T.G.
Duarte M.C.T.
Da Rosa M.F.
Meyer E.
Sarragiotto M.H.
Abstract: In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β- carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4- methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H- oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC 50 values of 0.48, 1.50 and 1.07 μM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed. © 2012 by the Authors.
Citation: Molecules. , v. 17, n. 5, p. 6100 - 6113, 2012.
Rights: aberto
Identifier DOI: 10.3390/molecules17056100
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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