Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/98397
Type: Artigo de periódico
Title: 1, 10 Phenanthroline, A Metal Chelator, Protects Against Alloxan- But Not Streptozotocin-induced Diabetes
Author: Eizric D.L.
de Lucio M.A.
Boschero A.C.
Hoffmann M.E.
Abstract: The iron chelator, 1,10-phenanthroline (Phen), which inhibits hydroxyl radical formation, was tested in vitro and in vivo against alloxan and streptozotocin (STZ) cytotoxicity. Phen injection reduced the severity of alloxan-induced diabetes in rats and attenuated alloxan-induced toxicity in human fibroblastas (VA 13 line) in culture. These protective effects were not observed against STZ toxic action. These results are consistent with the hypothesis that hydroxyl radicals, generated via an iron-catalyzed reaction, induce the alloxan but not the STZ diabetogenic effects. © 1987 Pergamon Journals Ltd.
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Rights: fechado
Identifier DOI: 10.1016/S0748-5514(86)80069-1
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0022917625&partnerID=40&md5=fa48fbffcbf245ca3e8501095cc3632a
Date Issue: 1986
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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